A Thiol-Mediated Three-Step Ring Expansion Cascade for the Conversion of Indoles into Functionalized Quinolines
نویسندگان
چکیده
An operationally simple, high yielding three-step cascade process is described for the direct conversion of indole-tethered ynones into functionalized quinolines. A single “multitasking” thiol reagent used to promote a dearomatizing spirocyclization, nucleophilic substitution, and one-atom ring expansion reaction under remarkably mild conditions. In addition, novel route thio-oxindoles described, which was discovered by serendipity.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.1c00205